The short answer
The Toyota Sienna wins on fuel economy and starting price; the Honda Odyssey wins on cargo flexibility and reliability rank. The Sienna is hybrid-only at 36 mpg combined versus the Odyssey's 22 mpg, and starts about $1,540 less. The Odyssey counters with more cargo room — roughly 38.6 cubic feet behind the third row — and second-row seats that fold and remove. Neither earned a 2025 IIHS award.
Which is more reliable — the Toyota Sienna or Honda Odyssey?
They are close. RepairPal scores both the Toyota Sienna and Honda Odyssey 3.5 out of 5.0, but the Odyssey ranks higher — 3rd among 8 minivans versus the Sienna's 6th — and costs slightly less to repair, about $547 a year against $554 for the Sienna. Both comfortably beat the minivan segment average of $647 a year.
The two are effectively tied on the headline score, with the Odyssey holding a modest edge on rank and annual repair cost — a difference of about $7 a year that few owners would notice. The per-model figures come from RepairPal's Toyota Sienna profile and its Honda Odyssey profile, which weight average repair cost, frequency, and severity. For the wider picture, see our guide to the most reliable car brands.
- Toyota Sienna: 3.5/5.0, ranked 6th of 8 minivans, ~$554/year in repairs.
- Honda Odyssey: 3.5/5.0, ranked 3rd of 8 minivans, ~$547/year in repairs.
- Both: below the $647/year minivan segment-average repair cost.
Which gets better gas mileage?
The Sienna, by a wide margin. The hybrid-only 2025 Toyota Sienna earns 36 mpg combined in front-wheel drive, while the gas-only 2025 Honda Odyssey returns 22 mpg combined — roughly a 64% efficiency advantage for the Sienna. The Odyssey is sold only with a 3.5L V6 and offers no hybrid to match it, so the Sienna wins fuel economy outright.
That powertrain split is the defining trade-off between these two: every 2025 Sienna is a hybrid, while every 2025 Odyssey is gas. EPA estimates vary by drivetrain, so match like for like — the Sienna's optional all-wheel drive dips slightly to 35 mpg combined. The figures below come from the EPA fuel-economy data for the 2025 models.
| 2025 powertrain (EPA combined) | Toyota Sienna | Honda Odyssey |
|---|---|---|
| Hybrid, FWD | 36 mpg (36 city / 36 hwy) | Not offered |
| Hybrid, AWD | 35 mpg (34 city / 36 hwy) | Not offered |
| Gas V6, FWD | Not offered | 22 mpg (19 city / 28 hwy) |
Which minivan has more passenger and cargo space?
The Odyssey, on cargo. Both seat eight, but the Honda Odyssey holds about 38.6 cubic feet behind the third row versus roughly 33.5 for the Toyota Sienna, and about 91 cubic feet behind the second row versus about 75.2. The reason is design: the Odyssey's second-row seats fold and remove, while the Sienna's do not, which caps its maximum cargo.
Those cargo figures are approximate, drawn from third-party specification listings rather than a single manufacturer sheet, so treat them as directional. The practical takeaway is real, though — if you regularly haul bikes, plywood, or moving boxes, the Odyssey's removable second row gives it a flat, longer load floor the hybrid Sienna can't match. The Sienna trades that flexibility for its hybrid efficiency.
- Toyota Sienna: 8 seats; ~33.5 cu ft behind 3rd row, ~75.2 cu ft behind 2nd row (approximate). Second row does not fold flat or remove.
- Honda Odyssey: 8 seats; ~38.6 cu ft behind 3rd row, ~91 cu ft behind 2nd row (approximate). Second row folds and removes.
- Test-fit: if maximum cargo matters, the Odyssey's removable seats are the deciding feature.
Which is safer according to crash tests?
Neither earned a 2025 IIHS award. In the institute's updated moderate overlap front test, the Toyota Sienna rated Marginal and the Honda Odyssey rated Poor, both flagged for the forces measured on a rear-seat occupant. The Sienna's Marginal is the better of two weak results, but neither minivan qualifies as an IIHS Top Safety Pick for the 2025 model year.
The IIHS published findings under the headline that minivans don't make the grade on rear-seat safety, citing elevated head and neck forces on rear dummies across the class. Confirm the current results before you buy, since ratings can shift by trim and model year. Read the institute's report at IIHS on minivan rear-seat safety and check federal star ratings at NHTSA's ratings tool.
- Toyota Sienna: Marginal in the updated moderate overlap front test; no 2025 IIHS award.
- Honda Odyssey: Poor in the updated moderate overlap front test; no 2025 IIHS award.
- Class-wide: the IIHS found minivans broadly weak on rear-seat occupant protection.
Which minivan is cheaper to buy?
The Sienna. The 2025 Toyota Sienna LE starts around $40,680 with destination ($39,185 plus a $1,495 fee), while the 2025 Honda Odyssey now opens at its EX-L trim near $42,220 because Honda discontinued the base LX and EX. That makes the Sienna about $1,540 cheaper at base — and it includes a hybrid powertrain, where the Odyssey is gas only.
The comparison is base-to-base on a delivered price; both climb steeply on higher trims. The Sienna LE price is confirmed in Toyota's Sienna pressroom; the Odyssey EX-L figure is per Edmunds and may vary by region and dealer — treat it as a secondary source. See our guide to the annual cost to own a car for how price, fuel, and upkeep add up beyond the sticker.
- Toyota Sienna LE (hybrid, base): about $40,680 with destination.
- Honda Odyssey EX-L (gas, base): about $42,220 (secondary source; LX and EX discontinued).
- Gap: the Sienna is roughly $1,540 less at base and is the only hybrid of the two.
Is the Sienna's hybrid worth the price over a gas minivan?
Yes, for most buyers. The Sienna's 36 mpg combined delivers roughly $700 a year in fuel savings over the Odyssey's 22 mpg, and the Sienna also starts about $1,540 less at base. The real trade-off is cargo flexibility: the Sienna's second row does not fold flat or remove, so the Odyssey hauls more.
That fuel estimate is approximate and swings with gas prices and how many miles you drive — a 15,000-mile-a-year family sees the gap sooner than a 6,000-mile one, so run your own numbers. Pick the Sienna if efficiency and a lower buy-in matter most; pick the Odyssey if maximum cargo and a removable second row outweigh the fuel difference. Compare the full picture using our cost-to-own guide.
- Pick the Sienna if: you want 36 mpg, the lower base price, and don't need to remove seats.
- Pick the Odyssey if: you regularly haul bulky loads and value the removable second row.
- Either way: the Odyssey offers no hybrid, so the efficiency edge is unique to the Sienna.
Frequently asked questions
Which is more reliable, the Toyota Sienna or Honda Odyssey?
They are close. RepairPal scores both the Toyota Sienna and Honda Odyssey 3.5 out of 5, but the Odyssey ranks higher — 3rd among 8 minivans versus the Sienna's 6th — and costs slightly less to repair, about $547 a year against $554. Both beat the segment average of $647 a year.
Which gets better gas mileage, the Sienna or Odyssey?
The Sienna, by a wide margin. The hybrid-only 2025 Toyota Sienna earns 36 mpg combined in front-wheel drive, while the gas-only 2025 Honda Odyssey returns 22 mpg combined — about 64% more efficiency for the Sienna. The Odyssey offers no hybrid to match it, so the Sienna wins fuel economy outright.
Which minivan has more passenger and cargo space?
The Odyssey on cargo. Both seat eight, but the Odyssey holds about 38.6 cubic feet behind the third row versus roughly 33.5 for the Sienna, and about 91 cubic feet behind the second row versus about 75.2. The Odyssey's second-row seats fold and remove; the Sienna's do not, which limits its maximum cargo.
Which is safer according to crash tests, the Sienna or Odyssey?
Neither earned a 2025 IIHS award. In the updated moderate overlap front test the Toyota Sienna rated Marginal and the Honda Odyssey rated Poor, both flagged for rear-seat occupant protection. The Sienna's Marginal is the better of two weak results, but neither minivan is an IIHS Top Safety Pick for 2025.
Which minivan is cheaper to buy, the Sienna or Odyssey?
The Sienna. The 2025 Toyota Sienna LE starts around $40,680 with destination, while the 2025 Honda Odyssey now opens at the EX-L trim near $42,220 because Honda dropped the base LX and EX. That makes the Sienna about $1,540 cheaper at base, and it includes a hybrid powertrain.
Is the Sienna's hybrid worth the price over a gas minivan?
The Sienna's 36 mpg combined delivers roughly $700 a year in fuel savings over the Odyssey's 22 mpg for an average-mileage driver, and the Sienna also starts about $1,540 less. The trade-off is cargo flexibility — the Sienna's second row does not fold flat or remove, so the Odyssey hauls more.
Sources
CarsLens is editorial guidance, not individualized advice. This comparison draws on RepairPal, the EPA (fueleconomy.gov), the IIHS, Toyota's Sienna pressroom, and Edmunds.